Ferroptosis-IN-3 (Compound 25) is a ferroptosis inhibitor. Ferroptosis-IN-3 inhibits RSL3-induced ferroptosis (EC 50 : 8.6 nM in HT-1080 cells). Ferroptosis-IN-3 scavenges DPPH and ABTS radicals (EC 50 : 3.94 and 6.3 μM respectively). Ferroptosis-IN-3 decreases lipid peroxidation.
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