PVD-06

Overview

PVD-06 is a selective PROTAC PTPN2 degrader with a DC 50 of 217 nM (selectivity index >60-fold over PTP1B). PVD-06 induces PTPN2 degradation via a VHL-, ubiquitin, and proteasome-dependent pathway. PVD-06 can promote T cell activation and amplify IFN-γ -mediated anticancer activity. PVD-06 can be used to further investigate PTPN2 in diseases such as leukemia and melanoma. (Pink: PTPN2 ligand ( HY-168691 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-B0236 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > STAT | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > IFNAR

Product Information

• Catalog No.: HY-149760
• CAS No.: 3032975-48-4
• Molecular Formula: C48H55F4N9O11S2
• Molecular Weight: 1074.13
• Purity: 98.30%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.33 mM); Clear solution
• Availability: In-stock

Source

Original product source