LC-MB12

Overview

LC-MB12 is an orally active PROTAC compound targets FGFR2 degradation with a DC 50 of 11.8 nM. LC-MB12 contains BGJ398 (a FGFR2 inhibitor ), PROTAC linker and CRBN.LC-MB12 inhibits FGFR2 signaling in gastric cancer cells and has anti-tumor activity. (Pink: FGFR2 ligand ( HY-160013 ); Blue: Cereblon ligand ( HY-W069604 ); Black: linker ( HY-Y1176 )).

Application

Products | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Gastric Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > FGFR

Product Information

• Catalog No.: HY-149843
• CAS No.: 2828438-38-4
• Molecular Formula: C43H44Cl2N10O8
• Molecular Weight: 899.78
• Purity: 98.10%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source