SCH79797 dihydrochloride

Overview

SCH79797 dihydrochloride is a highly potent, selective nonpeptide protease activated receptor 1 ( PAR1 ) antagonist. SCH79797 dihydrochloride inhibits binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC 50 of 70 nM and a K i of 35 nM. SCH79797 dihydrochloride inhibits thrombin-induced platelet aggregation with an IC 50 of 3 μM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. SCH79797 dihydrochloride also potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes.

Application

Products | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Protease Activated Receptor (PAR) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-14994
• CAS No.: 1216720-69-2
• Molecular Formula: C23H27Cl2N5
• Molecular Weight: 444.40
• Purity: 99.91%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Availability: In-stock

Source

Original product source