Pipamperone (Floropipamide) is a butyrophenone derivative and high-affinity antagonist of 5-HT 2A receptor ( pK i =8.2) and D 4 receptor ( pK i =8.0). Pipamperone is also a low-affinity antagonist of D 2 receptor ( pK i =6.7). Pipamperone affects neurotransmitter functions and exerts antipsychotic activity. Pipamperone is used in the research of mental disorders such as autism-related behavioral disorders and Alzheimer's disease.
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