SD-91

Overview

SD-91 ( STAT3 degrader-2), a product of the hydrolysis of SD-36 ( HY-129602 ), is a selective PROTAC-based STAT3 degrader with a K i of 5.5 nM. SD-91 displays >300-fold selectivity over other STAT family protein members. SD-91 potently induces degradation of STAT3 protein in cells. SD-91 has anticancer effects, such as myeloid leukemia, lymphoma (Pink: ligand for target protein ( HY-150895 ); Black: linker; Blue: E3 ligase ligand; E3 ligase ligand+linker: HY-176506). (Pink: STAT3 ligand ( HY-150895 ); Blue: E3 ligase ligand; Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-150251
• CAS No.: 2497583-03-4
• Molecular Formula: C59H62N9O13P
• Molecular Weight: 1136.15
• Purity: 97.49%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source