SM875

Overview

SM875 is a cellular prion protein ( PrP ) degrader ( IC 50 : 7.87 μM). SM875 targets PrP folding intermediates and promotes its degradation through the autophagy-lysosomal pathway. SM875 only acts on nascent, immature PrP molecules and has no effect on mature PrP before synthesis. SM875 can inhibit prion replication and has potential in the study of neurodegenerative diseases (i.e., prion diseases).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Prion Protein

Product Information

• Catalog No.: HY-150286
• CAS No.: 919023-94-2
• Molecular Formula: C19H16BrN3O3
• Molecular Weight: 414.25
• Purity: 98.89%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.04 mM); Clear solution
• Availability: In-stock

Source

Original product source