Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC 50 value of 10.30 μM for MAO-B , and 96.33% inhibition of Aβ 1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H 2 O 2 -induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease.
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