Y-27632 (Standard)

Overview

Y-27632 (Standard) is the analytical standard of Y-27632 ( HY-10071 ). This product is intended for research and analytical applications. Y-27632 is a ROCK inhibitor with K i values of 220 nM and 300 nM for ROCK1 and ROCK2 , respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the Rac1/NOX1/ROS/AKT/PAK1 signaling cascade.

Application

Products | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Others | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PAK | Products > Signaling Pathways > NADPH Oxidase | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > ROCK | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-10071R
• CAS No.: 146986-50-7
• Molecular Formula: C14H21N3O
• Molecular Weight: 247.34
• Purity: 98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source