MS159 is a potent nuclear receptor binding SET structural domain protein 2 ( NSD2 ) PROTAC degrader. MS159 inhibits the growth of tumour cells. MS159 is a useful chemical tool for exploring the role of NSD2 in health and disease. (Pink: NSD2 ligand ( HY-48149 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker).
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