PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC 50 s of 3.5 and 15 nM for PDE4 and PDE7 , respectively ( SI =2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs).
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphodiesterase (PDE)
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