Antitubercular agent-32 is a derivate of Benzothiazinone ( HY-13579A ), inhibits M. tuberculosis , and shows improved metabolic stability and enhanced water solubility. Antitubercular agent-32 exerts antitubercular effect by targeting decaprenylphosphoryl-β-D-ribose 2’-oxidase ( DprE1 , IC 50 =3.9 μM).
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