FXR antagonist 1

Overview

FXR antagonist 1 (compound F6) is an orally active and selective intestinal FXR antagonist ( IC 50 =2.1 μM). FXR antagonist 1 selectively inhibits intestinal FXR signalling through antagonism of intestinal FXR and feedback activation of hepatic FXR to improve hepatic steatosis, inflammation and fibrosis in NASH (nonalcoholic steatohepatitis) models. FXR antagonist 1 can be used in NASH studies.

Application

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Product Information

• Catalog No.: HY-151481
• CAS No.: 2295804-68-9
• Molecular Formula: C36H59NO5
• Molecular Weight: 585.86
• Purity: 99.85%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (4.27 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source