PfGSK3/PfPK6-IN-1

Overview

PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC 50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research.

Application

Products | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Plasmodium Infection | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Infection | Products > Signaling Pathways > Ser/Thr Kinase | Products > Signaling Pathways > Parasite | Products > Signaling Pathways > GSK-3

Product Information

• Catalog No.: HY-151574
• CAS No.: 2797225-49-9
• Molecular Formula: C22H23Cl2N5O2S
• Molecular Weight: 492.42
• Purity: 99.38%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.08 mM); Clear solution
• Availability: In-stock

Source

Original product source