dBRD4-BD1

Overview

dBRD4-BD1 is a selective and durable BRD4 degrader with an DC 50 value of 280 nM (D max =77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1. (Pink: BRD4 ligand ( HY-151594 ); Blue: Cereblon ligand ( HY-103597 ); Black: linker ( HY-W006445 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-151593
• CAS No.: 2839318-19-1
• Molecular Formula: C50H53F3N8O9
• Molecular Weight: 967.00
• Purity: 98.02%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.59 mM); Clear solution
• Availability: In-stock

Source

Original product source