SARS-CoV-2 Mpro-IN-5 is a dual Inhibitor of Main Protease ( M Pro ) and Cathepsin L ( CatL ), with IC 50 s of 1800 nM and 145 nM respectively. SARS-CoV-2 Mpro-IN-5 has antiviral activity against SARS-CoV2. SARS-CoV-2 Mpro-IN-5 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC 50 value of 14.7 nM.
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