MS6105

Overview

MS6105 is a PROTAC degrader targeting LDHA and LDHB , with DC 50 values of 38 nM and 74 nM for degrading LDHA and LDHB in PANC-1 cells, respectively, and no hook effect is observed at high concentrations. MS6105 inhibits the proliferation of pancreatic cancer cells, and no obvious toxicity is observed after intraperitoneal administration in mice. MS6105 can be used for pancreatic cancer-related research. (Pink: LDHA and LDHB ligand ( HY-175562 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-128421 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Malate Dehydrogenase (MDH)

Product Information

• Catalog No.: HY-152261
• CAS No.: 2891709-58-1
• Molecular Formula: C65H81N9O9S3
• Molecular Weight: 1228.59
• Purity: 99.2%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source