2-PMPA (2-(Phosphonomethyl)pentanedioic acid) is a glutamate carboxypeptidase II ( GCPII ) inhibitor with an IC 50 of 0.0003 μM. 2-PMPA shows low blood-brain barrier penetration. 2-PMPA sodium blocks the hydrolysis of NAAG , regulates glutamate levels in the brain and neurovascular coupling. 2-PMPA is applicable to the research of neurological diseases.
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