NMT-IN-1

Overview

NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase ( TbNMT ) inhibitor, with an IC 50 of 31 μM against TbNMT and an IC 50 of 66 μM against hNMT . As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-153021
• CAS No.: 326879-46-3
• Molecular Formula: C15H14N2OS
• Molecular Weight: 270.35
• Purity: 98.0%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source