BDM-2

Overview

BDM-2 is an IN-LEDGF allosteric inhibitor (INLAI) of HIV-1 integrase (IN refers to integrase) ( IC 50 =47 nM) with potent anti- Retroviral (ARV) activity. BDM-2 shows IN multimerization activation effect with an AC 50 value of 20 nM. BDM-2 blocks the interaction between the catalytic core domain of IN (IN-CCD) and the Integrase binding domain of LEDGF/p75 (IBD), with an IC 50 value of 0.15 μM. BDM-2 exhibits highly selective and favorable cytotoxicity.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > HIV | Products > Signaling Pathways > HIV Integrase

Product Information

• Catalog No.: HY-153094
• CAS No.: 1643876-33-8
• Molecular Formula: C25H30O4
• Molecular Weight: 394.50
• Purity: 99.15%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (6.34 mM); Clear solution
• Availability: In-stock

Source

Original product source