HEC96719

Overview

HEC96719 is a selective and orally active tricyclic farnesoid X receptor ( FXR ) agonist with EC 50 values of 1.37 and 1.55 nM by time-resolved fluorescence energy transfer (TR-FRET) and luciferase reporter assays, respectively. HEC96719 significantly improves non-alcoholic steatohepatitis (NASH) and liver fibrosis with favorable tissue distribution in liver and intestine. HEC96719 can be used for the research of non-alcoholic steatohepatitis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > FXR

Product Information

• Catalog No.: HY-153114
• CAS No.: 2181834-03-5
• Molecular Formula: C29H22Cl2N2O5
• Molecular Weight: 549.40
• Purity: 98.01%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 5 mg/mL (9.10 mM); Clear solution; Need ultrasonic and warming and heat to 80°C
• Availability: In-stock

Source

Original product source