Org 274179-0

Overview

Org 274179-0 is a potent and allosteric antagonist of thyroid-stimulating hormone (TSH) receptor, with an IC 50 of nanomolar concentration. Org 274179-0 completely inhibits TSH (and TSI)-mediated TSH receptor activation with little effect on the potency of TSH. Org 274179-0 can be used for the research of Graves' disease (GD).

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > TSH Receptor

Product Information

• Catalog No.: HY-153213
• CAS No.: 1421683-12-6
• Molecular Formula: C28H27F3N2O2
• Molecular Weight: 480.52
• Purity: 98.63%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.20 mM); Clear solution
• Availability: In-stock

Source

Original product source