P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H + /K + -ATPase activity with an IC 50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC 50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine ( HY-B1204 )-induced gastric acid secretion.
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