Silevertinib

Overview

Silevertinib (BDTX-1535) is an irreversible, brain-penetrant, selective and orally active EGFR inhibitor with wild-type EGFR-sparing. Silevertinib targets key EGFR resistance mutations, including the kinase domain ( C797S , L718Q , G724S , S768I ), extracellular domain ( EGFRvIII , A289X ), and EGFR amplification. Silevertinib exerts anti-tumor activity with well tolerated in vivo. Silevertinib can be used for non-small cell lung cancer (NSCLC) and glioblastoma (GBM) research.

Application

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Product Information

• Catalog No.: HY-153268
• CAS No.: 2607829-38-7
• Molecular Formula: C30H30ClFN6O2
• Molecular Weight: 561.05
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.46 mM); Clear solution
• Availability: In-stock

Source

Original product source