TMX1

Overview

TMX1 is a covalent, selective BRD4 molecular glue degrader. TMX1 binds to the JQ1-binding site of BRD4BD2 , forms covalent bonds with Cys58 of DCAF16 and Cys87 of GAK in a BRD4BD2 -dependent template-assisted manner, stabilizes the BRD4 -TMX1- DCAF16 ternary complex, and promotes the ubiquitination of BRD4 via the CRL4 DCAF16 ubiquitin ligase complex. TMX1 induces selective degradation of BRD4 , mild degradation of BRD2 and BRD3 , as well as DCAF16-dependent cytotoxicity.

Application

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Product Information

• Catalog No.: HY-153385
• CAS No.: 3079093-92-5
• Molecular Formula: C26H28N4O3S
• Molecular Weight: 476.59
• Purity: 99.57%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (5.25 mM); Clear solution
• Availability: In-stock

Source

Original product source