LG100268

Overview

LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC 50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 displays >1000-fold selectivity for RXR over RAR, the K i values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively. LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Autophagy | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > RAR/RXR | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-15340
• CAS No.: 153559-76-3
• Molecular Formula: C24H29NO2
• Molecular Weight: 363.49
• Purity: 99.39%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 0.56 mg/mL (1.54 mM); Clear solution
• Availability: In-stock

Source

Original product source