Timapiprant

Overview

Timapiprant (OC000459) is a potent, selective, and orally active D prostanoid receptor 2 ( DP 2 , also known as CRTH2 ) antagonist. Timapiprant (OC000459) potently displaces [ 3 H] PGD2 from human recombinant DP 2 ( K i =13 nM), rat recombinant DP 2 ( K i =3 nM), and human native DP 2 ( K i =4 nM). Timapiprant (OC000459) inhibits mast cell activation of Th2 lymphocytes and eosinophils.

Application

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Product Information

• Catalog No.: HY-15342
• CAS No.: 851723-84-7
• Molecular Formula: C21H17FN2O2
• Molecular Weight: 348.37
• Purity: 98.03%
• Storage: 4°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 0.4 mg/mL (1.15 mM); Clear solution
• Availability: In-stock

Source

Original product source