Trovirdine hydrochloride

Overview

Trovirdine hydrochloride, a phenethylthiazolylthiourea (PETT) derivative, is an HIV reverse transcriptase (RT) non-nucleoside inhibitor (NNI). A novel computer model of the RT/NNI binding pocket revealed spatial gaps around Trovirdine hydrochloride's pyridyl ring. Docking studies suggested that replacing this planar ring with a nonplanar piperidinyl or piperazinyl ring could better occupy the binding pocket, enhancing anti-HIV activity. Synthesized heterocyclic compounds based on this modification demonstrated greater potency than Trovirdine hydrochloride, effectively inhibiting HIV replication at nanomolar concentrations without cytotoxicity in infected peripheral blood mononuclear cells.

Application

Products | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Others | Products > Signaling Pathways > Reverse Transcriptase

Product Information

• Catalog No.: HY-15350
• CAS No.: 148311-89-1
• Molecular Formula: C13H14BrClN4S
• Molecular Weight: 373.70
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source