(RS)-4C3HPG (4-Carboxy-3-hydroxyphenylglycine) is an effective competitive antagonist at the metabotropic glutamate receptor 1 ( mGluR1 ) in the central nervous system, and it is also an agonist at mGluR2/3 . (RS)-4C3HPG exhibits neuroprotective effects in an acute global ischemia rat model.
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