LD4172

Overview

LD4172 is a selective RIPK1 PROTAC degrader with a K i of 4.8 nM. LD4172 induces RIPK1 protein degradation via ternary complex formation with RIPK1 and VHL E3 ligase , driving ubiquitination and proteasomal breakdown . LD4172 abrogates TNF-induced classical NF-κB signaling in TRAF2 -deficient cells, impairing IκBα phosphorylation and degradation, and reducing IL-8 production . LD4172 induces apoptosis and immunogenic cell death in tumor cells, enhances tumor-infiltrating lymphocyte responses, and sensitizes tumors to anti-PD1 therapy . LD4172 acts as a chemical probe for investigating RIPK1 scaffolding functions . LD4172 can be used for the research of melanoma, colon cancer . (Pink: RIPK1 Target protein ligand; Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-W012241 )).

Application

Products | Products > Disease Areas > Melanoma | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer Immunology | Products > Disease Areas > Immunotherapy for Melanoma | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-153598
• CAS No.: 2782022-40-4
• Molecular Formula: C61H75F3N10O7S
• Molecular Weight: 1149.37
• Purity: 98.32%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source