MRL-436 is a RNA polymerase inhibitor with antibacterial activity. MRL-436 exerts its antibacterial activity dependent on residue 622 of the RNA polymerase β' subunit and the RNAP ω subunit. MRL-436 inhibits Rifampicin ( HY-B0272 )-resistant RNA polymerase derivatives and exhibits antibacterial activity against Rifampicin -resistant strains.
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