ERK-CLIPTAC

Overview

ERK-CLIPTAC is a ERK CLIPTAC (click chemistry-synthesized proteolysis-targeting chimera) degrader. ERK-CLIPTAC forms intracellularly via click chemistry from ERK1/2-IN-14 (HY-175578) and Tz-thalidomide ( HY-101460 ). The formed ERK-CLIPTAC recruits the E3 ubiquitin ligase CRBN to ERK1/2 , thereby inducing ubiquitination and subsequent degradation of ERK1/2. Due to its lack of cell permeability, ERK-CLIPTAC cannot induce ERK1/2 degradation in cells. ERK-CLIPTAC can be used in research related to melanoma and colorectal cancer . (Pink: ERK1 and ERK2 Target protein ligand; Blue: Cereblon ligand ( HY-101460 ); Black: linker).

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Melanoma | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-153735
• CAS No.: 2087490-46-6
• Molecular Formula: C60H61ClN12O9
• Molecular Weight: 1129.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source