GBD-9

Overview

GBD-9 is a degrader based on the E3 ubiquitin ligase CRBN that targets BTK and the G1 to S phase transition protein GSPT1 . GBD-9 has both PROTAC and molecular glue properties by inducing ubiquitination and proteasomal degradation of target proteins. GBD-9 can efficiently degrade wild-type and mutant BTK (such as C481S mutation) and GSPT1. GBD-9 significantly inhibits tumor cell proliferation by inducing G1 phase arrest in cancer cells, downregulating anti-apoptotic proteins ( BCL-2 , MCL-1 ) and activating Caspase-3 to induce apoptosis . GBD-9 is mainly used in the research of hematological tumors such as diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML). GBD-9 is composed of E3 ubiquitin ligase ligand (pink part) 5-Aminothalidomide ( HY-W023573 ), target protein ligand (blue part) Btk Inhibitor: IBT6A ( HY-13036A ), and PROTAC linker (black part) Nonanoic acid ( HY-N7057 ). (Pink: Btk ligand ( HY-13036A ); Blue: Cereblon ligand ( HY-W023573 ); Black: linker ( HY-N7057 )).

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk | Products > Signaling Pathways > Molecular Glues

Product Information

• Catalog No.: HY-153803
• CAS No.: 2864408-92-2
• Molecular Formula: C44H47N9O6
• Molecular Weight: 797.90
• Purity: 99.91%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source