Mosnodenvir

Overview

Mosnodenvir (JNJ-1802) is an orally active pan serotype dengue virus ( DENV ) inhibitor, with EC 50 values ranging from 0.057 to 11 nM for four dengue virus ( DENV ) serotypes. Mosnodenvir blocks viral replication by inhibiting the formation of complexes between two viral proteins , nonstructural protein 3 (NS3) and NS4B, thereby preventing the formation of new viral RNA. Mosnodenvir exhibits picomolar to nanomolar antiviral activity in vitro and has antiviral efficacy in mice and non-human primates.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Viral Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Virus Protease | Products > Signaling Pathways > Dengue Virus | Products > Signaling Pathways > Flavivirus

Product Information

• Catalog No.: HY-153810
• CAS No.: 2890688-86-3
• Molecular Formula: C26H22ClF3N2O6S
• Molecular Weight: 582.98
• Purity: 99.77%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.29 mM); Clear solution
• Availability: In-stock

Source

Original product source