NR-7h

Overview

NR-7h is a potent and selective PROTAC degrader that targets and degrades p38α/β MAPK via cereblon recruitment. In T47D and MDA-MB-231 cells, the DC 50 values of NR-7h for degrading p38α are 24 nM and 27.2 nM, respectively, while those for degrading p38β are 48.47 nM and 48.90 nM, respectively. NR-7h blocks stress- and cytokine-induced p38α signaling pathways. NR-7h can be used in studies related to breast cancer , other cancers, visceral leishmaniasis, malaria, Mayaro fever, and coronavirus infection . (Pink: p38α and p38β ligand ( HY-403098 ); Blue: Cereblon ligand ( HY-103596 ); Black: linker).

Application

Products | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Leishmania Infection | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-153932
• CAS No.: 2550399-06-7
• Molecular Formula: C48H50BrF2N9O8
• Molecular Weight: 998.87
• Purity: 96.88%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source