Darusentan

Overview

Darusentan (Lu-135252) is a selective endothelin receptor A ( ET-A ) receptor antagonist, which binds with a K i of 1.4 nM to the ET-A receptor and a K i of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a K i of 13 nM.

Application

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Product Information

• Catalog No.: HY-15404
• CAS No.: 171714-84-4
• Molecular Formula: C22H22N2O6
• Molecular Weight: 410.42
• Purity: 98.60%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.08 mg/mL (5.07 mM); Clear solution
• Availability: In-stock

Source

Original product source