PTD10

Overview

PTD10 is a selective and potent BTK PROTAC degrader ( DC 50 = 0.5 nM, K D = 2.28 nM). PTD10 can recruit cereblon (CRBN) E3 ligase and form a ternary complex with BTK , thereby mediating the ubiquitination and proteasome-dependent degradation of BTK . PTD10 inhibits cancer cells proliferation, and induces cell apoptosis via activation of the caspase -dependent pathway and mitochondrial pathway. PTD10 potently inhibits the BCR, AKT and NF-κB signaling pathway. PTD10 can be used for researches of B-cell malignancies and autoimmune disease. (Pink: Btk ligand ( HY-19834 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-Y0966 )).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Akt | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-154860
• CAS No.: 2642231-19-2
• Molecular Formula: C49H51N11O8
• Molecular Weight: 922.00
• Purity: 97.38%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source