RSV L-protein-IN-5 (compound E) is a potent inhibitor of Respiratory syncytial virus ( RSV ) ( EC 50 =0.1 μM). RSV L-protein-IN-5 inhibits Polymerase ( IC 50 =0.66 μM),and blocks RSV mRNA synthesis by inhibiting guanylation of viral transcripts. RSV L-protein-IN-5 shows moderate cytotoxicity (CC50=10.7 μM,HEp-2),also exhibits activity and lowers virus titers in mouse models of RSV infection .
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