NC-R17

Overview

NC-R17 is a PROTAC degrader that targets glutathione peroxidase 4 ( GPX4 ) for degradation by recruiting cereblon . With RSL3 as its parent core, NC-R17 binds non-covalently to GPX4. NC-R17 exhibits moderate GPX4 degradation activity in tumor cells and can be used in studies related to ferroptosis ( ferroptosis ) and tumors. (Pink: GPX4 ligand ( HY-135832 ); Blue: Cereblon ligand ( HY-A0003 ); Black: linker ( HY-169376 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-155075
• CAS No.: 3049087-34-2
• Molecular Formula: C53H67N7O7
• Molecular Weight: 914.14
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source