hAChE-IN-3 (compounds 5c) is a potent and blood-brain barrier permeable AChE , BuChE , MAO-B-IN-1 and BACE-1 inhibitor, with IC 50 values of 0.44, 0.08, 5.15 and 0.38 μM, respectively. hAChE-IN-3 has antioxidant activity and metal chelating ability. In addition, hAChE-IN-3 can bind to peripheral anion sites, and affect β amyloid and reduce Alzheimer's-associated neurodegeneration. hAChE-IN-3 has the potential for the research of Alzheimer's disease.
Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Monoamine Oxidase | Products > Signaling Pathways > Amyloid-β | Products > Signaling Pathways > Cholinesterase (ChE)
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