PROTAC BRD4 Degrader-22 is a BRD4 PROTAC degrader with a DC 50 of 0.59 nM. At high concentrations, PROTAC BRD4 Degrader-22 induces partial degradation of BRD3 and BRD2 , but exhibits selectivity for IKZF3 . PROTAC BRD4 Degrader-22 can be used in leukemia-related research. (Pink: BRD4 ligand ( HY-78695 ); Blue: Cereblon ligand ( HY-W879795 ); Black: linker ( HY-W010525 )).
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