Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT 2 receptor antagonist with a K i of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT 2 than for the 5-HT 1 receptor ( K i of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.
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