NA-184

Overview

NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC 50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC 50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI).

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Proteasome

Product Information

• Catalog No.: HY-155482
• CAS No.: 2688119-39-1
• Molecular Formula: C27H35ClN4O5
• Molecular Weight: 531.04
• Purity: 99.66%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (4.71 mM); Clear solution
• Availability: In-stock

Source

Original product source