RORγt inverse agonist 31 (14g) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist, with an IC 50 of 0.428 μM. RORγt inverse agonist 31 can alleviate the severity of Imiquimod ( HY-B0180 )-induced psoriasis in mice.
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