Auristatin E

Overview

Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 ( HY-15580 ), is linear peptides comprised of four amino acids .

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > ADC Payloads

Product Information

• Catalog No.: HY-15582
• CAS No.: 160800-57-7
• Molecular Formula: C40H69N5O7
• Molecular Weight: 732.01
• Purity: 99.86%
• Storage: 4°C, protect from light, stored under nitrogen * The compound is unstable in solutions, freshly prepared is recommended.
• Availability: In-stock

Source

Original product source