Morcamilast

Overview

Morcamilast (ME3183) is a potent, orally active, selective phosphodiesterase 4 ( PDE4 ) inhibitor, with IC 50 values of 1.28 nM, 2.33 nM and 1.63 nM against human PDE4A1A , PDE4B1 and PDE4D2 , respectively. Morcamilast inhibits the production of TNF-α , IL-12/23p40 , IL-23 , IL-17A , IL-4 , IL-5 and IL-13 in human PBMCs and T cells, and alleviates chronic Oxazolone ( HY-126360 )-induced dermatitis, Substance P ( HY-P0201 )-induced pruritus, Imiquimod ( HY-B0180 )-induced psoriasis-like dermatitis and LPS ( HY-D1056 )-induced arthritis . Morcamilast is used for the research of psoriasis, atopic dermatitis, psoriatic arthritis and other inflammatory and immune-related diseases.

Application

Products | Products > Disease Areas > Allergy | Products > Disease Areas > Arthritis | Products > Disease Areas > Psoriasis | Products > Disease Areas > Atopic Dermatitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Skin Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-155830
• CAS No.: 2231329-25-0
• Molecular Formula: C19H20F2N4O3S
• Molecular Weight: 422.45
• Purity: 98.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (11.84 mM); Clear solution
• Availability: In-stock

Source

Original product source