CB1R/AMPK modulator 1 (Compound 38-S) is an orally active CB1R/AMPK modulator, with an K i of 0.81 nM and an IC 50 of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK . CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity.
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