BD-1008 dihydrobromide

Overview

BD-1008 dihydrobromide is a nonselective σ receptor antagonist with K i s against σ1 receptor and σ2 receptor of 2 nM and 8 nM. The BD-1008 dihydrobromide has an extremely low affinity for the D2 receptor ( K i = 1112 nM) and dopamine transporter (DAT) ( K i > 10,000 nM). BD-1008 dihydrobromide significantly antagonizes dopamine release in the shell region of the nucleus accumbens via the σ₂ receptor. BD-1008 dihydrobromide blocks the self-administration behavior of σ agonists.BD-1008 dihydrobromide can be used for the study of addiction therapy that target the σ receptor.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Sigma Receptor

Product Information

• Catalog No.: HY-100966
• CAS No.: 138356-09-9
• Molecular Formula: C15H24Br2Cl2N2
• Molecular Weight: 463.08
• Purity: 98.07%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source