PIK5-12d

Overview

PIK5-12d is a PROTAC PIKfyve degrader ( DC 50 = 1.48 nM). PIK5-12d induces massive cytoplasmic vacuolization and blocks autophagic flux in multiple prostate cancer cells. PIK5-12d inhibits prostate cancer cell proliferation. PIK5-12d significantly suppresses tumor proliferation in mice bearing LTL-331R human prostate cancer PDX tumors. PIK5-12d can be used for the study of prostate cancer . (Pink: PIKfyve ligand ( HY-175631 ); Blue: VHL ligand ( HY-125845 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Autophagy | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > PIKfyve | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-155994
• CAS No.: 3036457-38-9
• Molecular Formula: C52H64N10O7S
• Molecular Weight: 973.19
• Purity: 99.15%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source