VHL-IN-1

Overview

VHL-IN-1 (Compound 30) is an E3 ligase VHL inhibitor with a K d value of 37 nM. VHL-IN-1 blocks VHL-mediated ubiquitination and degradation of HIF-1α . VHL-IN-1 stabilizes the protein levels of HIF-1α and hydroxylated HIF-1α , and induces the transcriptional activity of HIF-1α . VHL-IN-1 can be used for PROTAC development. VHL-IN-1 is applicable for cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase | Products > Signaling Pathways > Ligands for E3 Ligase | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-156106
• CAS No.: 3033117-53-9
• Molecular Formula: C28H37FN4O4S
• Molecular Weight: 544.68
• Purity: 99.84%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source